Coronavirus and Kawasaki diseases in children.

Coronavirus and Kawasaki diseases in children.



What is Kawasaki disease?

Kawasaki disease is a combination of many symptoms where fever is the primary symptom and mainly affects children under 5 years of age. This condition causes swelling of blood vessels throughout the body which is called Vasculitis. This results in high body temperature (102-104 degrees Fahrenheit), which lasts for about five days and is usually not reduced by taking paracetamol or other fever medications.

Symptoms of Kawasaki disease:


Other common symptoms include swollen lymph nodes on both sides of the neck, rash around the genitals, dark redness of the eyes, lips or tongue, and even blood on the soles of the feet. In some cases the child may have an aneurysm in the coronary artery. In many cases, the disease is mistaken for Scarlet Fever or Juvenile Rheumatoid Arthritis. Hopefully, Kawasaki disease will get better in 3-4 weeks in most cases. 


What is the cause of Kawasaki disease?

The exact cause of Kawasaki disease is still unknown. However, the idea is that in some cases, the body's immune system becomes too active to deal with a bacterial infection in children. As a result, it destroys germs as well as creates vasculitis in its own body. However, research is also talking about genetic involvement. However, it is not a contagious disease.

What is the relationship between coronavirus and Kawasaki disease?

We commonly know that Kavid-19 enters the human body, attacks the respiratory system, and manifests other associated symptoms, including acute respiratory distress. But this deadly virus not only attacks the respiratory system, it also greatly stimulates the body's immune system. The body's macrophage-phagocytic system is so active in dealing with the virus that all symptoms, such as Kawasaki disease, appear.

What does the research paper say?

Dr. Lucio Vargani and his team in The Lancet Journal reported on May 13 that the number of Kawasaki cases among children in the Italian province of Bergamo has increased 30-fold in the last five years, all of them Kavid-19 positive. And there is ample evidence of macrophage-phagocytic system activity in children. Encouraging success has been found in the treatment of Kawasaki and the same treatment.

Dr. Caroline Galeotti and her team in the journal "Nature Reviews" and Dr. Randolph Feldstein and his team reported in The New England Journal this June that Autoimmune Multisystem Inflammatory Syndrome is on the rise among 19 Kavid-positive children around the world. And Kawasaki disease is one of them.

Of the 17 children with autoimmune multi-system inflammatory syndrome (average age 7.3 years) in the United States, 84 (40%) had symptoms of Kawasaki and all had fever for 4-5 days. It is also worth noting that almost all of them have improved their treatment of Kawasaki disease.

Treatment of Kawasaki disease:

The most common treatment for Kawasaki is aspirin and immunoglobulin. However, Dr. Randolph and his team have had great success using immunoglobulins as well as gluco-corticoids, interleukin-6 inhibitors, and interleukin-1Ra inhibitors. However, if the symptoms of the disease appear, the treatment can not be given at home in any way, very soon to seek the help of a specialist doctor, to take the prescription from the hospital. It is hoped that Kavid-19 will be contagious but Kawasaki is not contagious and will return home in a few days if the disease is properly diagnosed.

 Read details: 
https://www.nature.com/articles/s41584-020-0448-7
https://www.nejm.org/doi/pdf/10.1056/NEJMoa2021680?articleTools=true


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